ChloroquineV1, Main, Exploration, bibRecord, 002873

Phenotyping of the glutathione S-transferase M1 polymorphism in Zimbabweans and the effects of chloroquine on blood glutathione S-transferases M1 and A

Identifieur interne : 002873 ( Main/Exploration ); précédent : 002872; suivant : 002874

Phenotyping of the glutathione S-transferase M1 polymorphism in Zimbabweans and the effects of chloroquine on blood glutathione S-transferases M1 and A

Auteurs : Stanley Mukanganyama [Zimbabwe] ; Collen M. Masimirembwa [Zimbabwe] ; Yogeshkumar S. Naik [Zimbabwe] ; Julia A. Hasler [Zimbabwe]

Source :

Clinica Chimica Acta [ 0009-8981 ] ; 1997.

RBID : ISTEX:78C7916392C31B6C07DA0876EBCE5AD9A1194C61

English descriptors

Teeft :
- Absorbance, Absorbance value, Absorbance values, Acta, Biochem, Biochem pharmacol, Chimica, Chloroquine, Chloroquine phosphate, Chloroquine treatment, Clinica, Clinica chimica acta, Discordant results, Elisa, Frequency distribution, Genotype, Genotyping, Glutathione, Gsta, Gsta levels, Gstm1, Gsts, Hepatic, Hepatocellular, Hepatocellular damage, Mukanganyama, Phenotype, Phenotyping, Positive control, Prophylactic, Serum gsta, Therapeutic dose, Therapeutic doses, Zimbabwean, Zimbabwean population.

Abstract

Abstract: The frequency of the null allele phenotype of glutathione S-transferase (GST) M1 was investigated in 114 Zimbabweans and results for a subset of 63 subsets were compared with genotyping by PCR. In addition, the effect of the antimalarial chloroquine on blood levels of GSTM1 and GSTA in 19 subjects was studied. Quantification of GSTs was by enzyme linked immunosorbent assays (ELISA). Thirty percent of the subjects were of the GSTM1 null phenotype. Comparison of results of phenotyping by ELISA and genotyping by PCR showed that 16% of samples were in discordance; unknown mutations in the GSTM1 gene in the Zimbabwean population may explain this observation. Chloroquine decreased levels of blood GSTM1 and GSTA by 50% or more. In populations treated with chloroquine, these decreases in GST activities might lead to compromised ability to detoxify xenobiotics, could confound GSTM1 phenotyping and might invalidate use of GSTA as an indicator of liver damage.

Url:

https://api.istex.fr/ark:/67375/6H6-WH5LNWKV-S/fulltext.pdf

DOI: 10.1016/S0009-8981(97)00104-6

Affiliations:

Zimbabwe

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Le document en format XML

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<term>Biochem pharmacol</term>
<term>Chimica</term>
<term>Chloroquine</term>
<term>Chloroquine phosphate</term>
<term>Chloroquine treatment</term>
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<term>Clinica chimica acta</term>
<term>Discordant results</term>
<term>Elisa</term>
<term>Frequency distribution</term>
<term>Genotype</term>
<term>Genotyping</term>
<term>Glutathione</term>
<term>Gsta</term>
<term>Gsta levels</term>
<term>Gstm1</term>
<term>Gsts</term>
<term>Hepatic</term>
<term>Hepatocellular</term>
<term>Hepatocellular damage</term>
<term>Mukanganyama</term>
<term>Phenotype</term>
<term>Phenotyping</term>
<term>Positive control</term>
<term>Prophylactic</term>
<term>Serum gsta</term>
<term>Therapeutic dose</term>
<term>Therapeutic doses</term>
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<front><div type="abstract" xml:lang="en">Abstract: The frequency of the null allele phenotype of glutathione S-transferase (GST) M1 was investigated in 114 Zimbabweans and results for a subset of 63 subsets were compared with genotyping by PCR. In addition, the effect of the antimalarial chloroquine on blood levels of GSTM1 and GSTA in 19 subjects was studied. Quantification of GSTs was by enzyme linked immunosorbent assays (ELISA). Thirty percent of the subjects were of the GSTM1 null phenotype. Comparison of results of phenotyping by ELISA and genotyping by PCR showed that 16% of samples were in discordance; unknown mutations in the GSTM1 gene in the Zimbabwean population may explain this observation. Chloroquine decreased levels of blood GSTM1 and GSTA by 50% or more. In populations treated with chloroquine, these decreases in GST activities might lead to compromised ability to detoxify xenobiotics, could confound GSTM1 phenotyping and might invalidate use of GSTA as an indicator of liver damage.</div>
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Phenotyping of the glutathione S-transferase M1 polymorphism in Zimbabweans and the effects of chloroquine on blood glutathione S-transferases M1 and A

Phenotyping of the glutathione S-transferase M1 polymorphism in Zimbabweans and the effects of chloroquine on blood glutathione S-transferases M1 and A

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri